Regulation of an <i>ATG7</i> - <i>beclin 1</i> Program of Autophagic Cell Death by Caspase-8

Abstract excerpt

Caspases play a central role in apoptosis, a well-studied pathway of programmed cell death. Other programs of death potentially involving necrosis and autophagy may exist, but their relation to apoptosis and mechanisms of regulation remains unclear. We define a new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death...

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