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Article

A peptide fragment of azurin induces a p53-mediated cell cycle arrest in human breast cancer cells

1 Oct 2009

Abstract excerpt

We report that amino acids 50 to 77 of azurin (p28) preferentially enter the human breast cancer cell lines MCF-7, ZR-75-1, and T47D through a caveolin-mediated pathway. Although p28 enters p53 wild-type MCF-7 and the isogenic p53 dominant-negative MDD2 breast cancer cell lines, p28 only induces a G(2)-M-phase cell cycle arrest and apoptosis in MCF-7 cells. p28 exerts its antiproliferative activity by reducing...

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PMID: 19808975
DOI: 10.1158/1535-7163.mct-09-0444

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