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The CDK inhibitor p21 is a novel target gene of ATF 4 and contributes to cell survival under ER stress

4 Oct 2017

Abstract excerpt

Activating transcription factor 4 (ATF4) is well known for its role in the endoplasmic reticulum (ER) stress response. ATF4 also transcriptionally induces multiple effectors that determine cell fate depending on cellular context. In addition, ATF4 can communicate both pro-apoptotic and pro-survival signals. How ATF4 mediates its prosurvival roles, however, requires further investigation. Here, we report that the...

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PMID: 28975618
DOI: 10.1002/1873-3468.12869

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