Article
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.
Genes & development - 15 Oct 2004
Krebs Luke T, Shutter John R, Tanigaki Kenji, Honjo Tasuku, Stark Kevin L, Gridley Thomas
Abstract excerpt
The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand exhibit haploinsufficient lethality because of defects in vascular remodeling. We also describe vascular defects in embryos homozygous for a mutation in the Rbpsuh gene, which encodes the primary transcriptional...
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