Article
Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.
Mechanisms of development - 1 Oct 2001
Villa N, Walker L, Lindsell C E, Gasson J, Iruela-Arispe M L, Weinmaster G
Abstract excerpt
Mice with targeted mutations in genes required for Notch signal transduction die during embryogenesis, displaying overt signs of hemorrhage due to defects in their vascular development. Surprisingly, directed expression of a constitutively active form of Notch4 within mouse endothelial cells produces a similar vascular embryonic lethality. Moreover, patients with mutations in Notch3 exhibit the cerebral vascular...
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