Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dosage-sensitive requirement for mouse Dll4 in artery development.

Genes & development - 15 Oct 2004

Duarte António, Hirashima Masanori, Benedito Rui, Trindade Alexandre, Diniz Patrícia, Bekman Evguenia, Costa Luís, Henrique Domingos, Rossant Janet

Abstract excerpt

Involvement of the Notch signaling pathway in vascular development has been demonstrated by both gain- and loss-of-function mutations in humans, mice, and zebrafish. In zebrafish, Notch signaling is required for arterial identity by suppressing the venous fate in developing artery cells. In mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arteries
Share to Endothelial Cells
Share to Gene Dosage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Intracellular Signaling Peptides and Proteins

Share to Ligands

Share to Mice, Mutant Strains

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 15466159
DOI: 10.1101/gad.1239004
PMCID: PMC529534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15466159-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dosage-sensitive requirement for mouse Dll4 in artery development.PMID 15466159Read ↗

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.Semantic proximity Read ↗

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.Semantic proximity Read ↗

Novel insights into the differential functions of Notch ligands in vascular formationSemantic proximity Read ↗

Notch signaling is essential for vascular morphogenesis in mice.Semantic proximity Read ↗

Vegfc/Flt4 signalling is suppressed by Dll4 in developing zebrafish intersegmental arteries.Semantic proximity Read ↗

Notch Signaling in Vascular DevelopmentSemantic proximity Read ↗

Notch function in the vasculature: insights from zebrafish, mouse and manSemantic proximity Read ↗

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle developmentSemantic proximity Read ↗

Bone Morphogenetic Proteins in Vascular Homeostasis and Disease.Semantic proximity Read ↗

Notch Signaling in Blood VesselsSemantic proximity Read ↗

<i>Tbx1</i>expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentSemantic proximity Read ↗

Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.