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Article

Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells.

Biochemical and biophysical research communications - 5 Nov 2004

Koga Miho, Hirano Katsuya, Hirano Mayumi, Nishimura Junji, Nakano Hitoo, Kanaide Hideo

Abstract excerpt

Estrogen has been reported to inhibit apoptosis in vascular endothelial cells. However, its precise mechanism still remains to be elucidated. Here we determined the role of Akt in the anti-apoptotic effect of estrogen. 17Beta-estradiol prevented the apoptosis induced by TNF-alpha in bovine aortic endothelial cells, as evaluated by double staining with fluorescein isothiocyanate-conjugated annexin V and propidium...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15465021
DOI: 10.1016/j.bbrc.2004.09.060

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Akt plays a central role in the anti-apoptotic effect of estrogen in endothelial cells.PMID 15465021Read ↗

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