Article
High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.
Cellular signalling - 1 Mar 2006
Ho Feng Ming, Lin Wan Wan, Chen Bing Chang, Chao Chien M, Yang Chia-Ron, Lin Lian Y, Lai Chih Chang, Liu Shing H, Liau Chiau S
Abstract excerpt
Our previous studies demonstrated that high glucose-induced apoptosis in human umbilical vein endothelial cells (HUVECs) is mediated by sequential activation of c-Jun N-terminal kinase (JNK) and caspase, and prevented by exogenous nitric oxide (NO). In this study we further elucidated the roles of the transcriptional factor NF-kappaB, phosphatidylinositol 3'-kinase (PI3K), Akt and endothelial nitric oxide...
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