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Article

Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2003

Simoncini Tommaso, Rabkin Elena, Liao James K

Abstract excerpt

OBJECTIVE: Nontranscriptional signaling mechanisms mediate some of the biological effects of estrogen, such as the rapid actions on the blood vessels. By interacting with phosphatidylinositol 3-kinase (PI3K), estrogen receptor (ER) alpha leads to activation of protein kinase Akt and to subsequent increase in endothelial nitric oxide synthase activity. Because PI3K is mainly a cytoplasmic complex, we studied the...

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Source

Identifiers

PMID: 12588759
DOI: 10.1161/01.atv.0000053846.71621.93

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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