Article
The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP.
The Journal of biological chemistry - 9 Jan 2004
Skurk Carsten, Maatz Henrike, Kim Hyo-Soo, Yang Jiang, Abid Md Ruhul, Aird William C, Walsh Kenneth
Abstract excerpt
FLICE-inhibitory protein (FLIP) is a homolog of caspase-8 that lacks catalytic activity and has been shown to be important in protecting endothelial cells from apoptosis. The serine/threonine kinase Akt/PKB was recently reported to promote FLIP expression in endothelial and tumor cells. Here we examined the role of the forkhead transcription factor FOXO3a, a downstream target of Akt, in controlling FLIP...
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