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Article

Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.

Oncogene - 11 Sept 2003

Stoica Gerald E, Franke Thomas F, Moroni Maria, Mueller Susette, Morgan Elisha, Iann Mary C, Winder Abigail D, Reiter Ronald, Wellstein Anton, Martin Mary Beth, Stoica Adriana

Abstract excerpt

Epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I), and heregulin-beta1 (HRG-beta1), can modulate the expression and activity of the estrogen receptor-alpha (ER-alpha) via the phosphatidylinositol 3-kinase (PI 3-K)/Akt pathway in the ER-alpha-positive breast cancer cell line, MCF...

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Identifiers

PMID: 12970748
DOI: 10.1038/sj.onc.1206769

Genes

EGF
EGFR
HRG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12970748-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Effect of estradiol on estrogen receptor-alpha gene expression and activity can be modulated by the ErbB2/PI 3-K/Akt pathway.PMID 12970748Read ↗

Estradiol rapidly activates Akt via the ErbB2 signaling pathway.Semantic proximity Read ↗

A role for Akt in mediating the estrogenic functions of epidermal growth factor and insulin-like growth factor I.Semantic proximity Read ↗

In vivo and in vitro regulation of Akt activation in human endometrial cells is estrogen dependent.Semantic proximity Read ↗

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.Semantic proximity Read ↗

Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells.Semantic proximity Read ↗

Molecular basis of cell membrane estrogen receptor interaction with phosphatidylinositol 3-kinase in endothelial cells.Semantic proximity Read ↗

Modification of gene expression induced by siRNA targeting of estrogen receptor α in MCF7 human breast cancer cellsSemantic proximity Read ↗

Egr‐1 is activated by 17β‐estradiol in MCF‐7 cells by mitogen‐activated protein kinase‐dependent phosphorylation of ELK‐1Semantic proximity Read ↗

Enhanced estrogen receptor (ER) alpha, ERBB2, and MAPK signal transduction pathways operate during the adaptation of MCF-7 cells to long term estrogen deprivation.Semantic proximity Read ↗

Induction of hTERT expression and phosphorylation by estrogen via Akt cascade in human ovarian cancer cell linesSemantic proximity Read ↗

Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen.Semantic proximity Read ↗

Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt.Semantic proximity Read ↗

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