Article
Genetic diversity of chicken anemia virus following cell culture passaging in MSB-1 cells.
Acta virologica - 1 Jan 2004
Hasmah M S, Omar A R, Wan K F, Hair-Bejo M, Aini I
Abstract excerpt
It has been shown that a chicken anemia virus (CAV) isolates which had undergone 60 passages in MSB-1 cells (SMSC-1/P60, 3-1/P60) acquired 33-66 nucleotide substitutions at the coding region resulting in 13-16 amino acid changes as compared to the CAV isolates passaged only 5 times in MSB-1 cells (SMSC-1 and 3-1) (Chowdhury et al., Arch. Virol. 148, 2437-2448, 2003). In this study we found that a low CAV (BL-5)...
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