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Article

Dynamic equilibrium of Marek's disease genomes during in vitro serial passage.

Virus genes - 1 Dec 2012

Spatz Stephen J, Volkening Jeremy D, Gimeno Isabel M, Heidari Mohammad, Witter Richard L

Abstract excerpt

Attenuation of Gallid herpesvirus-2 (GaHV-2), the causative agent of Marek's disease, can occur through serial passage of a virulent field isolate in avian embryo fibroblasts. In order to gain a better understanding of the genes involved in attenuation and associate observed changes in phenotype with specific genetic variations, the genomic DNA sequence of a single GaHV-2 virulent strain (648A) was determined at...

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PMID: 22923089
DOI: 10.1007/s11262-012-0792-z

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