Article
Modified vaccinia Ankara strains with identical coding sequences actually represent complex mixtures of viruses that determine the biological properties of each strain.
Vaccine - 9 Dec 2009
Suter Mark, Meisinger-Henschel Christine, Tzatzaris Maria, Hülsemann Vanessa, Lukassen Susanne, Wulff Niels Holger, Hausmann Jürgen, Howley Paul, Chaplin Paul
Abstract excerpt
Modified vaccinia Ankara (MVA) was developed by serial passages on chicken embryo fibroblast cells. After passage 570, the virus was considered homogenous and genetically stable. Three MVA strains (MVA-572, MVA-I721 and MVA-BN) have been analyzed and shown to be 100% genetically identical; although significant differences in their phenotypes were illustrated. All MVA strains except MVA-BN replicated in human...
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