Article
Mutations occurring during serial passage of Japanese equine infectious anemia virus in primary horse macrophages.
Virus research - 1 Jun 2000
Zheng Y H, Sentsui H, Kono Y, Ikuta K
Abstract excerpt
An attenuated equine infectious anemia virus (EIAV), named V26, was previously obtained after 50 passages of the Japanese virulent strain V70 in primary macrophage culture. To clarify the differences between both viruses, their full-length sequences were determined. There were higher mutations in S2 (6.15% amino acid difference) and LTR (10.7% nucleotide difference). The presumed initiation codon of the S2 gene...
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