Article
Development and exploitation of CK2 inhibitors.
Molecular and cellular biochemistry - 1 Jun 2005
Sarno Stefania, Ruzzene Maria, Frascella Pietrogiulio, Pagano Mario A, Meggio Flavio, Zambon Alfonso, Mazzorana Marco, Di Maira Giovanni, Lucchini Vittorio, Pinna Lorenzo A
Abstract excerpt
A number of quite specific and fairly potent inhibitors of protein kinase CK2, belonging to the classes of condensed polyphenolic compounds, tetrabromobenzimidazole/triazole derivatives and indoloquinazolines are available to date. The structural basis for their selectivity is provided by a hydrophobic pocket adjacent to the ATP/GTP binding site, which in CK2 is smaller than in the majority of other protein...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.