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Article

Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.

Journal of medicinal chemistry - 2 Dec 2004

Pagano Mario A, Andrzejewska Mariola, Ruzzene Maria, Sarno Stefania, Cesaro Luca, Bain Jenny, Elliott Matthew, Meggio Flavio, Kazimierczuk Zygmunt, Pinna Lorenzo A

Abstract excerpt

Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and infective diseases. Thus, CK2 inhibitors designed to dissect the signaling pathways affected by th...

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Identifiers

PMID: 15566294
DOI: 10.1021/jm049854a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15566294-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole.PMID 15566294Read ↗

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