Article
Immunogenicity of recombinant type IX collagen in murine collagen-induced arthritis.
Arthritis and rheumatism - 1 Apr 2002
Myers L K, Pihlajamaa T, Brand D D, Cremer M A, Bodo M, Ala-Kokko L, Kang A H
Abstract excerpt
OBJECTIVE: Past attempts to isolate type IX collagen (CIX) from cartilage using limited proteolysis yielded partially degraded material. Recent application of recombinant technology, however, has allowed the preparation of intact native CIX. We used the murine collagen-induced arthritis model to characterize the immunologic properties of recombinant human CIX (rCIX) produced using a baculovirus expression system....
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