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Article

Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

24 Mar 2004

Abstract excerpt

Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB-MYH11. We have previously shown that CBFB-MYH11 is necessary but not sufficient for leukemogenesis. Here, we report the identification of genes that specifically cooperate with CBFB-MYH11 in leukemogenesis. Neonatal injection of Cbfb-MYH11 knock-in chimeric mice with retrovirus 4070A...

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PMID: 15044690
DOI: 10.1073/pnas.0400930101

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