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Article

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

28 May 2002

Abstract excerpt

Constitutive activation of tyrosine kinases, such as the BCR/ABL fusion associated with t(9;22)(q34;q22), is a hallmark of chronic myeloid leukemia (CML) syndromes in humans. Expression of BCR/ABL is both necessary and sufficient to cause a chronic myeloproliferative syndrome in murine bone marrow transplantation models, and absolutely depends on kinase activity. Progression of CML to acute leukemia (blast...

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PMID: 12032333
DOI: 10.1073/pnas.102583199

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