Article
Myosin VI plays a role in cell-cell adhesion during epithelial morphogenesis.
Mechanisms of development - 1 Nov 2004
Millo Hadas, Leaper Kevin, Lazou Vasiliki, Bownes Mary
Abstract excerpt
Myosin VI is an unconventional Myosin that has been implicated in vesicle transport and membrane trafficking. We isolated lethal mutants of Myosin VI, which lack protein once maternal supplies have been utilised during embryogenesis. Dorsal closure, where there is a ring of Myosin VI at the edge of the migrating epithelial sheet, is often abnormal. The sheet of migrating cells is irregular, rather than a smooth...
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