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Article

Genetic variants modify the associations of concentrations of methylmalonic acid, vitamin B-12, vitamin B-6, and folate with bone mineral density.

The American journal of clinical nutrition - 2 Aug 2021

Liu Ching-Ti, Karasik David, Xu Hanfei, Zhou Yanhua, Broe Kerry, Cupples L Adrienne, Cpgm de Groot Lisette, Ham Annelies, Hannan Marian T, Hsu Yi-Hsiang, Jacques Paul, McLean Robert R, Paul Ligi, Selhub Jacob, Trajanoska Katerina, van der Velde Nathalie, van Schoor Natasja, Kiel Douglas P

Abstract excerpt

BACKGROUND: Elevated plasma homocysteine has been found to be associated with an increased risk of osteoporosis, especially hip and vertebral fractures. The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine β-synthase...

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Identifiers

PMID: 33964857
DOI: 10.1093/ajcn/nqab093
PMCID: PMC8326042

Genes

CBS
MTHFR
MTR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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