Article
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
The Journal of cell biology - 10 Oct 2005
Yu W Haung, Cuervo Ana Maria, Kumar Asok, Peterhoff Corrinne M, Schmidt Stephen D, Lee Ju-Hyun, Mohan Panaiyur S, Mercken Marc, Farmery Mark R, Tjernberg Lars O, Jiang Ying, Duff Karen, Uchiyama Yasuo, Näslund Jan, Mathews Paul M, Cataldo Anne M, Nixon Ralph A
Abstract excerpt
Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity. In this study, we show that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before beta-amyloid (Abeta) deposits extracellularly in the presenilin (PS) 1/Abeta precursor protein (APP) mouse model of beta-amyloidosis. Subsequently,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.