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Article

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons.

The Journal of cell biology - 10 May 2004

Wilson Christina A, Murphy Diane D, Giasson Benoit I, Zhang Bin, Trojanowski John Q, Lee Virginia M-Y

Abstract excerpt

Presenilin-1 null mutation (PS1 -/-) in mice is associated with morphological alterations and defects in cleavage of transmembrane proteins. Here, we demonstrate that PS1 deficiency also leads to the formation of degradative vacuoles and to the aberrant translocation of presynaptic alpha- and bet...

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Identifiers

PMID: 15123735
DOI: 10.1083/jcb.200403061
PMCID: PMC2172178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15123735-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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