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Article

Metabolism of sirolimus in the presence or absence of cyclosporine by genotyped human liver microsomes and recombinant cytochromes P450 3A4 and 3A5.

Drug metabolism and disposition: the biological fate of chemicals - 1 Mar 2007

Picard Nicolas, Djebli Nassim, Sauvage François-Ludovic, Marquet Pierre

Abstract excerpt

Sirolimus is an immunosuppressive drug currently used alone or in combination with cyclosporine. Both drugs undergo extensive metabolism by the CYP 3A enzymes. This study aimed at comparing the activity of recombinant CYP (rCYP) 3A4 and 3A5 toward sirolimus, investigating the effect of cyclosporine on the metabolic rate of these two cytochromes P450 (P450s), as well as the impact of the CYP 3A5*3 polymorphism on...

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Share to Cyclosporine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 Enzyme System

Share to Immunosuppressive Agents

Share to Microsomes, Liver

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 17151193
DOI: 10.1124/dmd.106.012161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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