Article
Association studies of MAO-A, COMT, and 5-HTT genes polymorphisms in patients with anxiety disorders of the phobic spectrum.
Psychiatry research - 30 Aug 2004
Samochowiec Jerzy, Hajduk Anna, Samochowiec Agnieszka, Horodnicki Jan, Stepień Genowefa, Grzywacz Anna, Kucharska-Mazur Jolanta
Abstract excerpt
Recent studies provide evidence that anxiety disorders may be linked to malfunction of serotonin neurotransmission or impaired activity of enzymes metabolising the catecholamines. Functional polymorphisms in the MAO-A uVNTR promoter gene, the COMT gene (Val158Met) exon 4, and the 5-HTT promoter gene (44 bp ins/del) were investigated in 101 patients with phobic disorders of the anxiety spectrum and 202 controls...
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