Article
Haloperidol rescues the schizophrenia-like phenotype in adulthood after rotenone administration in neonatal rats.
Psychopharmacology - 1 Sept 2021
Varga Thiago Garcia, de Toledo Simões Juan Guilherme, Siena Amanda, Henrique Elisandra, da Silva Regina Cláudia Barbosa, Dos Santos Bioni Vinicius, Ramos Aline Camargo, Rosenstock Tatiana Rosado
Abstract excerpt
Neuropsychiatric disorders are multifactorial disturbances that encompass several hypotheses, including changes in neurodevelopment. It is known that brain development disturbances during early life can predict psychosis in adulthood. As we have previously demonstrated, rotenone, a mitochondrial complex I inhibitor, could induce psychiatric-like behavior in 60-day-old rats after intraperitoneal injections from...
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