TP53 Arg72Pro polymorphism and neuroblastoma susceptibility in eastern Chinese children: a three-center case-control study.

doi:10.1042/BSR20200854

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TP53 Arg72Pro polymorphism and neuroblastoma susceptibility in eastern Chinese children: a three-center case-control study.

Bioscience reports - 29 May 2020

Fang Yuan, Wu Xuemei, Li Lin, Zhu Jinhong, Wu Haiyan, Zhou Haixia, He Jing, Wang Yizhen

Abstract excerpt

TP53 is a tumor suppressor gene that regulates cell growth, apoptosis and DNA repair. Previous studies have reported the contribution of TP53 Arg72Pro (rs1042522 C>G) polymorphism to pathogenesis of multiple tumors. Hence, we evaluated the association between this polymorphism and neuroblastoma susceptibility in eastern Chinese children. The Taqman genotyping assay was performed in 373 patients and 762 controls....

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PMID: 32406493
DOI: 10.1042/BSR20200854
PMCID: PMC7244897

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