Article
O6-methylguanine DNA methyltransferase gene promoter methylation status in gliomas and its correlation with other molecular alterations: first Indian report with review of challenges for use in customized treatment.
Neurosurgery - 1 Dec 2010
Jha Prerana, Suri Vaishali, Jain Ayushi, Sharma Mehar Chand, Pathak Pankaj, Jha Pankaj, Srivastava Arti, Suri Ashish, Gupta Deepak, Chosdol Kunzang, Chattopadhyay Parthoprasad, Sarkar Chitra
Abstract excerpt
BACKGROUND: O6-methylguanine methyltransferase (MGMT) promoter methylation in adult glioblastomas (glioblastoma multiforme) is considered a promising molecular alteration, predictive of better response to temozolomide therapy and longer overall survival. OBJECTIVE: To look at the frequency of MGMT methylation in glial tumors of all grades and types, and correlate this alteration with loss of heterozygosity...
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