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Article

Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)

29 May 2015

Abstract excerpt

O-6-methylguanine-DNA methyltransferase (MGMT) is an abundantly expressed nuclear protein dealkylating O6-methylguanine (O6-MG) DNA residue, thus correcting the mismatches of O6-MG with a thymine residue during DNA replication. The dealkylating effect of MGMT is relevant not only in repairing DNA mismatches produced by environmental alkylating agents promoting tumor pathogenesis, but also when alkylating...

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PMID: 26035292
DOI: 10.3892/ijo.2015.3026

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