Article
Apolipoprotein E genotype and cognitive dysfunction after noncardiac surgery.
Anesthesiology - 1 Oct 2004
Abildstrom Hanne, Christiansen Michael, Siersma Volkert D, Rasmussen Lars S
Abstract excerpt
BACKGROUND: Apolipoprotein E is important in recovery after neuronal damage. The epsilon4 allele of the apolipoprotein E gene has been shown as a risk factor for Alzheimer disease, poor outcome after cerebral injury, and accelerated cognitive decline with normal aging. The authors hypothesized that patients with the epsilon4 allele would have an increased risk of postoperative cognitive dysfunction (POCD) after...
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