Article
Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study.
Canadian journal of anaesthesia = Journal canadien d'anesthesie - 1 Jun 2015
Bartels Karsten, Li Yi-Ju, Li Yen-Wei, White William D, Laskowitz Daniel T, Kertai Miklos D, Stafford-Smith Mark, Podgoreanu Mihai V, Newman Mark F, Mathew Joseph P
Abstract excerpt
PURPOSE: Cognitive performance after cardiac surgery can be impaired, and genetic risk factors have previously been suggested. When compared with other isoforms of the gene, the apolipoprotein epsilon 4 (APOE4) allele is associated with worse outcomes in many neurologic disorders. We hypothesized that the APOE4 allele is associated with less favourable cognitive function five years after surgery. METHODS:...
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