Article
A prospective cohort study evaluating associations among delirium, postoperative cognitive dysfunction, and apolipoprotein E genotype following open aortic repair.
Canadian journal of anaesthesia = Journal canadien d'anesthesie - 1 Mar 2011
Bryson Gregory L, Wyand Anna, Wozny Denise, Rees Laura, Taljaard Monica, Nathan Howard
Abstract excerpt
BACKGROUND: Patients undergoing major vascular surgery are at high risk of postoperative delirium and postoperative cognitive dysfunction (POCD). Apolipoprotein E (APOE) is involved in central acetylcholine synthesis, and patients bearing the ε4 genotype (APOE-ε4) are at increased risk of both vascular dementia and peripheral vascular disease. The purpose of this study was to evaluate the associations among...
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