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Article

Antiangiogenic therapy of cerebral melanoma metastases results in sustained tumor progression via vessel co-option.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2004

Leenders William P J, Küsters Benno, Verrijp Kiek, Maass Cathy, Wesseling Pieter, Heerschap Arend, Ruiter Dirk, Ryan Andy, de Waal Robert

Abstract excerpt

PURPOSE: In the brain, tumors may grow without inducing angiogenesis, via co-option of the dense pre-existent capillary bed. The purpose of this study was to investigate how this phenomenon influences the outcome of antiangiogenic therapy. EXPERIMENTAL DESIGN: Mice carrying brain metastases of the human, highly angiogenic melanoma cell line Mel57-VEGF-A were either or not treated with different dosages of ZD6474,...

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Identifiers

PMID: 15448011
DOI: 10.1158/1078-0432.CCR-04-0823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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