Article
Multimutated herpes simplex virus g207 is a potent inhibitor of angiogenesis.
Neoplasia (New York, N.Y.) - 1 Jan 2000
Cinatl Jindrich, Michaelis Martin, Driever Pablo Hernáiz, Cinatl Jaroslav, Hrabeta Jan, Suhan Tatyana, Doerr Hans Wilhelm, Vogel Jens-Uwe
Abstract excerpt
The mode of the antitumoral activity of multimutated oncolytic herpes simplex virus type 1 G207 has not been fully elucidated yet. Because the antitumoral activity of many drugs involves the inhibition of tumor blood vessel formation, we determined if G207 had an influence on angiogenesis. Monolayers of human umbilical vein endothelial cells and human dermal microvascular endothelial cells, but not human dermal...
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