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Article

Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2006

Moffat Bradford A, Chen Mark, Kariaapper Muhammed S T, Hamstra Daniel A, Hall Daniel E, Stojanovska Jadranka, Johnson Timothy D, Blaivas Mila, Kumar Mahesh, Chenevert Thomas L, Rehemtulla Alnawaz, Ross Brian D

Abstract excerpt

PURPOSE: Vascular endothelial growth factor (VEGF)-A is an important mediator of angiogenesis in almost all solid tumors. The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas. EXPERIMENTAL DESIGN: Stable 9L cell lines underexpressing and overexpressing VEGF-A were generated. Anatomic, susceptibility contrast,...

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PMID: 16533777
DOI: 10.1158/1078-0432.CCR-05-1408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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