Article
Route-dependent Dissemination with Conserved Blood–Tumor Barrier Ultrastructure in Intracranial Metastasis Models
2025-12-12
Abstract excerpt
<title>Abstract</title> <p>The dissemination route of brain metastases dictates their spatiotemporal distribution, but whether it alters the ultrastructural state of the blood-tumor barrier remains unresolved. Here, we compared a modified hematogenous dissemination model that minimizes extracranial signal confounds with a direct intracranial inoculation model. The hematogenous model produced multifocal brain lesi...
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Identifiers and source
- Literature Corpus work
- c3360e40-5b8a-5575-b453-3fb478d8482b
- DOI
- 10.21203/rs.3.rs-8038462/v1