Immunoglobulin heavy chain gene associations in myasthenia gravis: new evidence for disease heterogeneity.

doi:10.1007/BF00839214

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Article

Immunoglobulin heavy chain gene associations in myasthenia gravis: new evidence for disease heterogeneity.

Journal of neurology - 1 Jan 1992

Demaine A, Willcox N, Janer M, Welsh K, Newsom-Davis J

Abstract excerpt

Susceptibility to myasthenia gravis (MG) is known to involve genes residing in the major histocompatibility complex class I and II regions (HLA-B8 and DR3). Immunoglobulin heavy chain constant region (IgCH) allotypes have also shown some associations with MG. We have used restriction fragment length polymorphism analysis with probes to the IgCH switch (S) regions mu and alpha 1 and the downstream marker D14S1 to...

Topics

Adult
Age Factors
Autoantibodies
Autoimmune Diseases
Genes, Immunoglobulin
Genetic Predisposition to Disease
HLA-B7 Antigen
HLA-B8 Antigen
HLA-DR2 Antigen
HLA-DR3 Antigen
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Myasthenia Gravis

Receptors, Nicotinic

Thymoma

Thymus Neoplasms

White People

Source

Open in PubMed

Identifiers

PMID: 1541972
DOI: 10.1007/BF00839214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1541972-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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