Genetic association of Ctla-4 to myasthenia gravis with thymoma.

doi:10.1016/s0165-5728(98)00119-2

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Article

Genetic association of Ctla-4 to myasthenia gravis with thymoma.

Journal of neuroimmunology - 1 Aug 1998

Huang D, Liu L, Norén K, Xia S Q, Trifunovic J, Pirskanen R, Lefvert A K

Abstract excerpt

Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) plays a pivotal role in downregulating both the cellular and the humoral response by suppressing ongoing responses of activated T cells. Our earlier study showed that genetic variations in interleukin-1 genes confer susceptibility to myasthenia...

Topics

Abatacept
Adult
Alleles
Antigens, CD
Antigens, Differentiation
Autoimmune Diseases
CTLA-4 Antigen
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 6
Female
Gene Frequency
Genetic Markers
Humans
Immunoconjugates
Male
Myasthenia Gravis
Polymorphism, Genetic
Reference Values

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Identifiers

PMID: 9688341
DOI: 10.1016/s0165-5728(98)00119-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9688341-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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