Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.

doi:10.1016/j.clim.2016.05.003

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Article

Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.

Clinical immunology (Orlando, Fla.) - 1 May 2016

Saruhan-Direskeneli Güher, Hughes Travis, Yilmaz Vuslat, Durmus Hacer, Adler Adam, Alahgholi-Hajibehzad Mahdi, Aysal Fikret, Yentür Sibel P, Akalin Mehmet Ali, Dogan Oner, Marx Alexander, Gülsen-Parman Yesim, Oflazer Piraye, Deymeer Feza, Sawalha Amr H

Abstract excerpt

This study aims to investigate genetic susceptibility to early-onset and late-onset anti-acetylcholine receptor antibody positive myasthenia gravis (EOMG and LOMG) and anti-muscle specific kinase antibody positive MG (MuSK-MG) at genome-wide level in a single population. Using a custom-designed array and imputing additional variants and the classical HLA alleles in 398 patients, we detected distinct associations....

Topics

Age of Onset
Alleles
Female
Gene Frequency
Genetic Heterogeneity
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-B Antigens

HLA-C Antigens

HLA-DQ beta-Chains

Humans

Linkage Disequilibrium

Male

Myasthenia Gravis

Polymorphism, Single Nucleotide

Receptor Protein-Tyrosine Kinases

Source

Open in PubMed

Identifiers

PMID: 27181991
DOI: 10.1016/j.clim.2016.05.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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