Article
Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population.
PloS one - 1 Jan 2012
Maniaol Angelina H, Elsais Ahmed, Lorentzen Åslaug R, Owe Jone F, Viken Marte K, Sæther Hanne, Flåm Siri T, Bråthen Geir, Kampman Margitta T, Midgard Rune, Christensen Marte, Rognerud Anna, Kerty Emilia, Gilhus Nils Erik, Tallaksen Chantal M E, Lie Benedicte A, Harbo Hanne F
Abstract excerpt
BACKGROUND: Acquired myasthenia gravis (MG) is a rare antibody-mediated autoimmune disease caused by impaired neuromuscular transmission, leading to abnormal muscle fatigability. The aetiology is complex, including genetic risk factors of the human leukocyte antigen (HLA) complex and unknown environmental factors. Although associations between the HLA complex and MG are well established, not all involved...
Topics
- Adult
- Age of Onset
- Alleles
- Cohort Studies
- Female
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged
- Myasthenia Gravis