Article
IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset.
Journal of neuroimmunology - 1 Jan 2002
Sciacca Francesca L, Ferri Cinzia, Veglia Fabrizio, Andreetta Francesca, Mantegazza Renato, Cornelio Ferdinando, Franciotta Diego, Piccolo Giovanni, Cosi Vittorio, Batocchi Anna P, Evoli Amelia, Grimaldi Luigi M E
Abstract excerpt
Myasthenia gravis (MG) is a multifactorial autoimmune disease of the neuromuscular junction. We investigated the relation between four polymorphisms of the interleukin (IL)-1 gene cluster on 2q12-22, and MG susceptibility and clinical features in a large cohort of individuals. No polymorphism was associated with MG susceptibility. However, the IL-1A -889 CC genotype was associated with early disease onset...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Cohort Studies
- Disease-Free Survival
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin-1
- Male
- Middle Aged