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Article

Polymorphic markers in MHC class II/III region: a study on Italian patients with myasthenia gravis.

Journal of the neurological sciences - 15 Sept 2001

Franciotta D, Cuccia M, Dondi E, Piccolo G, Cosi V

Abstract excerpt

With an Italian case series of 81 Italian patients and 130 controls, we analysed associations between myasthenia gravis (MG) and genetic polymorphisms in the MHC class II/III region. Increases in the frequency of the TNF-B*1, C4A*Q0, C4B*1, DRB1*03 supratype, which is likely part of the 8.1 ancestral haplotype, were maximal in females with early onset (EO) MG vs. controls [p<0.05, relative risk (RR)=9.9]. These...

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PMID: 11574100
DOI: 10.1016/s0022-510x(01)00573-1

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TNF

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