Next-Generation Sequencing Identifies Extended HLA Class I and II Haplotypes Associated With Early-Onset and Late-Onset Myasthenia Gravis in Italian, Norwegian, and Swedish Populations.

doi:10.3389/fimmu.2021.667336

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Next-Generation Sequencing Identifies Extended HLA Class I and II Haplotypes Associated With Early-Onset and Late-Onset Myasthenia Gravis in Italian, Norwegian, and Swedish Populations.

Frontiers in immunology - 1 Jan 2021

Creary Lisa E, Gangavarapu Sridevi, Caillier Stacy J, Cavalcante Paola, Frangiamore Rita, Lie Benedicte A, Bengtsson Mats, Harbo Hanne Flinstad, Brauner Susanna, Hollenbach Jill A, Oksenberg Jorge R, Bernasconi Pia, Maniaol Angelina Hatlø, Hammarström Lennart, Mantegazza Renato, Fernández-Viña Marcelo A

Abstract excerpt

Genetic susceptibility to myasthenia gravis (MG) associates with specific HLA alleles and haplotypes at the class I and II regions in various populations. Previous studies have only examined alleles at a limited number of HLA loci that defined only broad serotypes or alleles defined at the protein sequence level. Consequently, genetic variants in noncoding and untranslated HLA gene segments have not been fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to HLA-B Antigens

Share to HLA-DR Antigens

Share to Italy

Share to Myasthenia Gravis

Share to Norway

Share to Sweden

Source

Open in PubMed Open full text

Identifiers

PMID: 34163474
DOI: 10.3389/fimmu.2021.667336
PMCID: PMC8215161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next-Generation Sequencing Identifies Extended HLA Class I and II Haplotypes Associated With Early-Onset and Late-Onset Myasthenia Gravis in Italian, Norwegian, and Swedish Populations.PMID 34163474Read ↗

Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population.Semantic proximity Read ↗

HLA-DQB1*05:02, *05:03, and *03:01 alleles as risk factors for myasthenia gravis in a Spanish cohort.Semantic proximity Read ↗

Human Leukocyte Antigen Class II associations in late‐onset Myasthenia GravisSemantic proximity Read ↗

Genetic heterogeneity within the HLA region in three distinct clinical subgroups of myasthenia gravis.Semantic proximity Read ↗

Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients.Semantic proximity Read ↗

Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis.Semantic proximity Read ↗

Juvenile myasthenia gravis in Norway: HLA-DRB1*04:04 is positively associated with prepubertal onset.Semantic proximity Read ↗

HLA and age of onset in myasthenia gravis.Semantic proximity Read ↗

Elucidating genetic backgrounds of myasthenia gravis in Japanese by genome-wide association studies and multi-omics analyses of thymoma.Semantic proximity Read ↗

Association of HLA-DQB1*05:02 and DRB1*16 Alleles with Late-Onset, Nonthymomatous, AChR-Ab-Positive Myasthenia GravisSemantic proximity Read ↗

Correlation Between the Prevalence of Myasthenia Gravis and the Frequency of Class II Human Leucocyte Antigen Alleles in Various Geographical Locations Around the WorldSemantic proximity Read ↗

HLA-genotyping by next-generation-sequencing reveals shared and unique HLA alleles in two patients with coexisting neuromyelitis optica spectrum disorder and thymectomized myasthenia gravis: Immunological implications for mutual aetiopathogenesis?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.