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Article

Brain parenchyma sonography detects preclinical parkinsonism.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2004

Walter Uwe, Klein Christine, Hilker Ruediger, Benecke Reiner, Pramstaller Peter P, Dressler Dirk

Abstract excerpt

Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult-onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound-heterozygous), compared to PMC with only one mutated allele...

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PMID: 15390070
DOI: 10.1002/mds.20232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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