Brain parenchyma sonography detects preclinical parkinsonism.

doi:10.1002/mds.20232

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Article

Brain parenchyma sonography detects preclinical parkinsonism.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2004

Walter Uwe, Klein Christine, Hilker Ruediger, Benecke Reiner, Pramstaller Peter P, Dressler Dirk

Abstract excerpt

Substantia nigra (SN) hyperechogenicity on brain parenchyma sonography (BPS) is highly characteristic for idiopathic PD. We studied 7 symptomatic and 7 asymptomatic parkin mutation carriers (PMC) from a large kindred with adult-onset parkinsonism. BPS revealed larger SN echogenic sizes in PMC with parkin mutations on both alleles (homozygous, compound-heterozygous), compared to PMC with only one mutated allele...

Topics

Adult
Aged
Aged, 80 and over
Alleles
Brain
Female
Fluorodeoxyglucose F18
Humans
Male
Middle Aged
Parkinson Disease
Point Mutation
Positron-Emission Tomography
Radiopharmaceuticals
Substantia Nigra
Ubiquitin-Protein Ligases
Ultrasonography

Source

Open in PubMed

Identifiers

PMID: 15390070
DOI: 10.1002/mds.20232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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