Article
Sonographic alteration of substantia nigra is related to parkinsonism-predominant course of X-linked dystonia-parkinsonism.
Parkinsonism & related disorders - 1 Apr 2017
Walter Uwe, Rosales Raymond, Rocco Alessandro, Westenberger Ana, Domingo Aloysius, Go Criscely L, Brüggemann Norbert, Klein Christine, Lee Lillian V, Dressler Dirk
Abstract excerpt
INTRODUCTION: X-linked recessive dystonia-parkinsonism (XDP, DYT3) is highly prevalent in the Philippines and manifests with varying phenotype. We sought to evaluate the significance of transcranial brain sonography as a biomarker for parkinsonism-predominant phenotype. METHODS: 90 Filipino participants were enrolled into a cross-sectional study: 39 patients with XDP, 21 asymptomatic first-degree relatives of XDP...
Topics
- Adult
- Case-Control Studies
- Disease Progression
- Dystonic Disorders
- Genetic Diseases, X-Linked
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Mutation
- Parkinsonian Disorders
- Philippines
- Substantia Nigra