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Article

Substantia nigra hyperechogenicity correlates with clinical status and number of Parkin mutated alleles.

Journal of neurology - 1 Oct 2007

Hagenah J M, König I R, Becker B, Hilker R, Kasten M, Hedrich K, Pramstaller P P, Klein C, Seidel G

Abstract excerpt

To further evaluate (1) transcranial sonography (TCS) for (pre)clinical diagnosis of Parkinson's disease (PD) and (2) to examine asymptomatic carriers of Parkin mutations we investigated substantia nigra (SN) hyperechogenicity in PD patients and unaffected subjects with and without Parkin mutations. The area (aSN) of the hyperechogenic SN were calculated bilaterally and study subjects were assigned to high versus...

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Identifiers

PMID: 17934880
DOI: 10.1007/s00415-007-0567-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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