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Article

Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease.

NeuroImage - 1 Feb 2003

Ruprecht-Dörfler Petra, Berg Daniela, Tucha Oliver, Benz Peter, Meier-Meitinger Michael, Alders Gesine L, Lange Klaus W, Becker Georg

Abstract excerpt

Increased echogenicity of the substantia nigra (SN) on ultrasound is a typical sonographic finding in Parkinson's disease (PD). Sonographic signal intensity of the SN is related to tissue iron content with higher iron level being associated with increased echogenicity. Recent findings indicate that hyperechogenicity of the SN represents an important susceptibility factor for nigrostriatal degeneration. In this...

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Identifiers

PMID: 12595195
DOI: 10.1016/s1053-8119(02)00035-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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