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Article

Substantia nigra hyperechogenicity with LRRK2 G2019S mutations.

Movement disorders : official journal of the Movement Disorder Society - 1 Apr 2011

Brüggemann Norbert, Hagenah Johann, Stanley Kaili, Klein Christine, Wang Cuiling, Raymond Deborah, Ozelius Laurie, Bressman Susan, Saunders-Pullman Rachel

Abstract excerpt

BACKGROUND: Transcranial sonography (TCS) area of hyperechogenicity in the substantia nigra (aSN) is increased in idiopathic and genetic Parkinson's disease (PD). METHODS: We performed TCS in 34 LRRK2 G2019S mutation carriers manifesting PD, 24 non-manifesting mutation carriers, and 28 idiopathic PD patients and compared them with 40 healthy controls (total, n = 126). RESULTS: Compared with the controls (mean...

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Identifiers

PMID: 21312285
DOI: 10.1002/mds.23644
PMCID: PMC3082617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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