Article
A hidden Markov modeling approach for admixture mapping based on case-control data.
Genetic epidemiology - 1 Nov 2004
Zhang Chun, Chen Kun, Seldin Michael F, Li Hongzhe
Abstract excerpt
Admixture mapping is potentially a powerful method for mapping genes for complex human diseases, when the disease frequency due to a particular disease-susceptible gene is different between founding populations of different ethnicity. The method tests for association of the allele ancestry with the disease. Since the markers used to define ancestral populations are not fully informative for the ancestry status,...
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